4-Chlorobenzaldehyde → HCID 117702898, compound

HRID 873910Notes

Reaction equation

HRID 873910 reaction equation
I[C:2]1[C:3]([CH3:20])=[N:4][N:5]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([O:18][CH3:19])[N:13]=2)[C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].[Cl:21][C:22]1[CH:29]=[CH:28][C:25]([CH:26]=[O:27])=[CH:24][CH:23]=1>CCCCCC.CCOC(C)=O>[Cl:21][C:22]1[CH:29]=[CH:28][C:25]([CH:26]([OH:27])[C:2]2[C:3]([CH3:20])=[N:4][N:5]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([O:18][CH3:19])[N:13]=3)[C:6]=2[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 77264-ChlorobenzaldehydeHCID 117702787HCID 117702787, compound

Product 1

HCID 117702898HCID 117702898, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 1.3 using ethyl 4-iodo-1-(2-methoxypyrimidin-4-yl)-3-methyl-1H-pyrazole-5-carboxylate (Step 59.3) and 4-chlorobenzaldehyde at RT for 60 min. tR: 5.20 min (HPLC 1); tR: 1.18 min (LC-MS 2); ESI-MS: 403 [M+H]+ (LC-MS 2); Rf=0.44 (hexane/EtOAc 1:1).

Sources & evidence

ORD record
ord-6aea32f9985e4036abc1a4ffe4ac7238
Source dataset
uspto-grants-2015_03
Patent number
US08975417B2

Reaction notes

Loading…