反应详情

温度

12.5 °C

A mixture of 100.1 g of metformin hydrochloride, 36.5 g of paraldehyde and 4 g of Dowex DR-2030 in 237.8 ml of isobutanol was heated under reflux for 6 hours. The catalyst was subsequently filtered off, and some of the solvent was removed by distillation. The remainder of the solution was cooled to 10-15° C., and the white precipitate was separated off, giving 93.5 g (80.7%) of 4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1,3,5-triazine hydrochloride.

1. temperaturewas heated
2. temperatureunder reflux for 6 hours
3. filtrationThe catalyst was subsequently filtered off
4. customsome of the solvent was removed by distillation
5. customthe white precipitate was separated off