Hydrochloric Acid → HCID 90388476, compound

HRID 874457Notes

Reaction equation

HRID 874457 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:14]([C:15]3[C:23]4[C:18](=[C:19]([O:24]C)[N:20]=[CH:21][CH:22]=4)[N:17]([CH3:26])[CH:16]=3)=[CH:13][C:12]([N+:27]([O-:29])=[O:28])=[CH:11][N:10]=2)=[CH:4][CH:3]=1.Cl>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[C:14]([C:15]3[C:23]4[CH:22]=[CH:21][NH:20][C:19](=[O:24])[C:18]=4[N:17]([CH3:26])[CH:16]=3)=[CH:13][C:12]([N+:27]([O-:29])=[O:28])=[CH:11][N:10]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 90387574HCID 90387574, compound

Product 1

HCID 90388476HCID 90388476, compound

Procedure

A mixture of Example 69b (0.25 g, 0.610 mmol) and hydrogen chloride (12.20 mL, 48.8 mmol, 4 M in dioxane) was heated at 90° C. overnight. The reaction mixture was cooled to ambient temperature, and the solvent was removed under reduced pressure to give the crude product, which was used directly for the next reaction.

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-32f94d7437f4417181bccff5324e534f
Source dataset
uspto-grants-2015_03
Patent number
US08980879B2

Reaction notes

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