反应详情

Ethyl 4-(3-chloro-4-methoxybenzyloxy)-2-(methylmercapto)pyrimidine-5-carboxylate (3.0 g, 8.15 mmol) and sodium hydroxide (652 mg, 16.3 mmol) were dissolved in 10 mL of water and 50 mL of THF, reacted at room temperature for 5 h. The diluted hydrochloric acid was added to adjust to pH=6, extraction was performed with dichloromethane (30 mL×3), the extract was dried and concentrated to obtain a white solid, and this product was directly used in the next reaction without purification.

1. extractionto adjust to pH=6, extraction
2. customthe extract was dried
3. concentrationconcentrated
4. customto obtain a white solid
5. customthis product was directly used in the next reaction without purification