反应详情

To a solution of 3-(1,3-dioxolan-2-yl)propyl 1-(4-((3-((S)-phenyl((((R)-quinuclidin-3-yloxy)carbonyl)amino)methyl)phenoxy)methyl)benzoyl)piperidine-4-carboxylate in THF (4.7 mL) was added 2 M aqueous hydrochloric acid (4.7 mL). The reaction mixture was stirred at RT for 4 hours. The reaction mixture was partitioned between saturated sodium hydrogen carbonate and ethyl acetate. The organic phase removed and the aqueous phase was extracted with further ethyl acetate (×2). The combined organic phases were washed with brine, dried (magnesium sulfate), filtered and the solvent evaporated at reduced pressure. The residue was used directly in the next step with no further purification.

1. customThe reaction mixture was partitioned between saturated sodium hydrogen carbonate and ethyl acetate
2. customThe organic phase removed
3. extractionthe aqueous phase was extracted with further ethyl acetate (×2)
4. washThe combined organic phases were washed with brine
5. dry with materialdried (magnesium sulfate)
6. filtrationfiltered
7. customthe solvent evaporated at reduced pressure
8. customThe residue was used directly in the next step with no further purification