Benzylamine → N-benzyl-2-(1,3-dioxolan-2-yl)ethanamine

To a mixture of benzylamine (2.18 mL, 20.0 mmol) and di-iso-propylethylamine (2.61 mL, 15.0 mmol) in acetonitrile (30 mL) was added 2-(2-bromoethyl)-1,3-dioxolane (1.17 mL, 10.0 mmol). The reaction mixture was stirred at room temperature for 72 hours. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic phase was dried (magnesium sulfate), filtered and the solvent evaporated at reduced pressure. The residue was purified by flash column chromatography eluting with 0 to 4% methanol/dichloromethane to afford the title compound (0.836 g, 40%).

1. washwashed with water and brine
2. dry with materialThe organic phase was dried (magnesium sulfate)
3. filtrationfiltered
4. customthe solvent evaporated at reduced pressure
5. customThe residue was purified by flash column chromatography
6. washeluting with 0 to 4% methanol/dichloromethane

ORD record

ord-a0285b814ca049f996ac3f2e4bd4e2b1

Source dataset

uspto-grants-2015_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08980913B2