Acetate → 5-Cyclopropyl-2-fluoropyridine

HRID 87488Notes

Reaction equation

HRID 87488 reaction equation
[C:39]([O-:40])(=[O:41])[CH3:42].[C:44]([O-:45])(=[O:46])[CH3:47].[CH:31]([OH:32])([CH3:33])[CH3:34].[CH:35]([Cl:36])([Cl:37])[Cl:38].[CH:9]1([B:12]([OH:13])[OH:14])[CH2:10][CH2:11]1.[F:1][c:2]1[n:3][cH:4][c:5]([I:8])[cH:6][cH:7]1.[K+:20].[K+:21].[K+:22].[OH2:23].[P:15]([O-:16])([O-:17])([O-:18])=[O:19].[Pd+2:43].[c:24]1([CH3:25])[cH:26][cH:27][cH:28][cH:29][cH:30]1>>[F:1][c:2]1[n:3][cH:4][c:5]([CH:9]2[CH2:10][CH2:11]2)[cH:6][cH:7]1

Participants

11

Reactant 10

HCID 175Acetate2×HCID 813Potassium Cation3×HCID 962WaterHCID 1061PhosphateHCID 1140TolueneHCID 3776IsopropanolHCID 6212ChloroformHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2760897Cyclopropylboronic acidHCID 27831792-Fluoro-5-iodopyridine

Product 1

HCID 576908315-Cyclopropyl-2-fluoropyridine

Sources & evidence

ORD record
ord-11e99c2723b0439090726063e6abe79e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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