反应详情

A solution of ethyl 1,5,5-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate (1.00 g, 4 mmol) in anhydrous ethyl formate (10 mL) was treated with sodium ethoxide (0.54 g, 8 mmol) and refluxed for 3 hours. The mixture was cooled to room temperature and poured into cold water (40 mL). The aqueous layer was washed with diethyl ether (40 mL) to remove unreacted starting material, acidified with a 20% NaH2PO4 solution and extracted with ethyl acetate (50 mL×2). The organic extracts were collected, dried on Na2SO4 and evaporated to dryness to obtain the title compound (0.88 g, 78.8% yield) as a brown solid.

1. temperaturerefluxed for 3 hours
2. washThe aqueous layer was washed with diethyl ether (40 mL)
3. customto remove unreacted
4. extractionextracted with ethyl acetate (50 mL×2)
5. customThe organic extracts were collected
6. customdried on Na2SO4
7. customevaporated to dryness