反应详情

温度

45 °C

4′-Bromomethyl-2-cyanobiphenyl (15 g, 0.0551 moles) was added to a mixture of potassium carbonate (19.05 g), DM water (45 ml), ethyl acetate (60 ml) and L-valine methyl ester hydrochloride (11.09 g, 0.066 moles) at 20-30° C. The reaction mixture was heated to 40-50° C. and stirred for 25 h. After completion of the reaction, the ethyl acetate layer was separated at 20-30° C., concentrated under reduced pressure and dissolved in o-xylene (90 ml)

1. customAfter completion of the reaction
2. customthe ethyl acetate layer was separated at 20-30° C.
3. concentrationconcentrated under reduced pressure
4. dissolutiondissolved in o-xylene (90 ml)