HCID 42599313, compound → HCID 42599314, compound

HRID 875265Notes

Reaction equation

HRID 875265 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH:15]2[C:19](=[O:20])[O:18][C@H:17]3[C:21]4[C@@:26]([CH3:29])([CH2:27][CH2:28][C:16]23[OH:31])[CH2:25][CH2:24][CH2:23][C:22]=4[CH3:30])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd].Cl>[OH:31][C:16]12[CH2:28][CH2:27][C@:26]3([CH3:29])[C:21](=[C:22]([CH3:30])[CH2:23][CH2:24][CH2:25]3)[C@@H:17]1[O:18][C:19](=[O:20])[CH:15]2[CH2:14][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 1

HCID 42599313HCID 42599313, compound

Product 1

HCID 42599314HCID 42599314, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 23938PalladiumSolvent

Conditions

Temperature
25 °C

Procedure

Compound of example 27 (100 mg, 0.24 mmol) was dissolved in ethanol (10 mL) and to it 10% Pd/C & 10% aqueous HCl (0.1 mL) was added. The reaction mixture was stirred under hydrogen pressure for 30 hours at room temperature (25° C.). The reaction mixture was filtered over celite and concentrated under reduced pressure to obtain the title compound.

Workup

  1. additionwas added
  2. filtrationThe reaction mixture was filtered over celite and
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-ee3e0b883b464427bce7198a86453008
Source dataset
uspto-grants-2015_03
Patent number
US08981131B2

Reaction notes

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