反应详情

21.98 g (127.66 mmol) of 5-oxo-5,6,7,8-tetrahydroquinoline-2-carbonitrile, 21.6 g (127.66 mmol) of 2-(5-fluoro-2-methoxyphenyl)ethanamine [CAS Reg.-No. 1000533-03-8] and 3.64 g (19.15 mmol) of p-toluenesulphonic acid monohydrate were dissolved in 511 ml of toluene, and the solution was stirred under reflux overnight using a water separator. 200 ml of toluene were then distilled off and, after cooling, replaced by fresh toluene. The reaction solution was then evaporated to dryness and the resulting residue was taken up in 511 ml of anhydrous ethanol and 511 ml of anhydrous THF. With stirring at a temperature of from 15° to 20° C., 9.66 g (255.32 mmol) of sodium borohydride were added a little at a time to the solution (careful: reaction mixture foams). The reaction solution was then stirred at the same temperature overnight. 10% strength aqueous sodium chloride solution was then added carefully, and the reaction mixture was extracted twice with ethyl acetate. The combined organic phases were dried over sodium sulphate, filtered and then concentrated to dryness. The residue obtained in this manner was purified by column chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 2:1). This gave 19.5 g (59.93 mmol, 46% of theory) of the target compound.

1. temperatureunder reflux overnight
2. distillation200 ml of toluene were then distilled off
3. temperatureafter cooling
4. customThe reaction solution was then evaporated to dryness
5. additionwere added a little at a time
6. customto the solution (careful: reaction mixture foams)
7. stirringThe reaction solution was then stirred at the same temperature overnight
8. extractionthe reaction mixture was extracted twice with ethyl acetate
9. dry with materialThe combined organic phases were dried over sodium sulphate
10. filtrationfiltered
11. concentrationconcentrated to dryness
12. customThe residue obtained in this manner
13. customwas purified by column chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 2:1)