Trimethyl orthoformate → HCID 67045291, compound

HRID 875792Notes

Reaction equation

HRID 875792 reaction equation
[Si:1]([O:8][CH2:9][CH:10]=O)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Cl.[NH2:13][C@@H:14]1[CH2:19][CH2:18][CH2:17][N:16]([C:20]2[C:25]([Br:26])=[CH:24][N:23]=[C:22]3[NH:27][CH:28]=[C:29]([NH:30][C:31](=[O:40])[C:32]4[CH:37]=[CH:36][C:35]([F:38])=[C:34]([Cl:39])[CH:33]=4)[C:21]=23)[CH2:15]1.CCN(C(C)C)C(C)C.C(OC)(OC)OC.[BH4-].[Na+].C([O-])(O)=O.[Na+]>CO.C(Cl)Cl>[Br:26][C:25]1[C:20]([N:16]2[CH2:17][CH2:18][CH2:19][C@@H:14]([NH:13][CH2:10][CH2:9][O:8][Si:1]([C:4]([CH3:5])([CH3:6])[CH3:7])([CH3:2])[CH3:3])[CH2:15]2)=[C:21]2[C:29]([NH:30][C:31](=[O:40])[C:32]3[CH:37]=[CH:36][C:35]([F:38])=[C:34]([Cl:39])[CH:33]=3)=[CH:28][NH:27][C:22]2=[N:23][CH:24]=1

Participants

9

Reactant 6

HCID 9005Trimethyl orthoformateHCID 81531DiisopropylethylamineHCID 516892Sodium BicarbonateHCID 41877882-((Tert-butyldimethylsilyl)oxy)acetaldehydeHCID 4311764Sodium borohydrideHCID 67045092HCID 67045092, compound

Product 1

HCID 67045291HCID 67045291, compoundYield 39.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

2-(tert-Butyldimethylsilyloxy)acetaldehyde (0.037 mL, 0.19 mmol) was added to a mixture of (R)—N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide (70 mg, 0.13 mmol, Example 62), DIEA (0.068 mL, 0.39 mmol), and trimethyl orthoformate (280 mg, 2.6 mmol) in MeOH (3 mL), and the reaction was stirred at room temperature for 18 hours. NaBH4 (9.8 mg, 0.26 mmol) was then added, and the reaction was stirred for 1 hour. The mixture was poured into a saturated solution of NaHCO3, and extracted with CH2Cl2. The combined organic fractions were dried (MgSO4), filtered, and concentrated in vacuo. The residue obtained was purified by column chromatography on silica gel eluting with 2% MeOH:CH2Cl2 to provide (R)—N-(5-bromo-4-(3-(2-(tert-butyldimethylsilyloxy)ethylamino)piperidin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-chloro-4-fluorobenzamide (32 mg, 39% yield).

Workup

  1. stirringthe reaction was stirred for 1 hour
  2. extractionextracted with CH2Cl2
  3. dry with materialThe combined organic fractions were dried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe residue obtained
  7. customwas purified by column chromatography on silica gel eluting with 2% MeOH

Sources & evidence

ORD record
ord-7d1d0f5e05da4a4480b0d80a9c7bd8f0
Source dataset
uspto-grants-2015_03
Patent number
US08981085B2

Reaction notes

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