反应详情

Was prepared from stirred a mixture of methyl 1H-pyrrole-2-carboxylate (3.04 g, 23.5 mmol), difluoroiodomethane (4.4 g, 24.7 mmol) and DMF (40 ml). Sodium hydride (1.41 g, 35.2 mmol) was added in portions during 30 minutes. The mixture was stirred for additional 15 minutes. Water (50 ml) was added and the mixture was extracted with dichloromethane. The mixture was purified by silica gel chromatography, using dichloromethane as solvent. The product was dried and evaporated. Yield 3.21 g (78%).

1. customWas prepared
2. stirringThe mixture was stirred for additional 15 minutes
3. extractionthe mixture was extracted with dichloromethane
4. customThe mixture was purified by silica gel chromatography
5. customThe product was dried
6. customevaporated