Hydrochloric Acid → HCID 86673656, compound

HRID 876159Notes

Reaction equation

HRID 876159 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.Cl>CC(O)C>[ClH:1].[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 709434,6-Dichloropyrimidine

Product 1

HCID 86673656HCID 86673656, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
84 °C

Procedure

250 mg of 4,6-dichloropyrimidine and 120 mg of aniline were dissolved in 2.5 mL of i-PrOH and 0.25 mL of 37% HCl was added. The mixture obtained was refluxed (84° C.) for 2.5 hours under nitrogen atmosphere. A colorless precipitate was formed which was collected by filtration. 6-Chloro-N-phenylpyrimidin-4-amine hydrochloride in the form of colorless crystals was obtained.

Workup

  1. customThe mixture obtained
  2. customA colorless precipitate was formed which
  3. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-05e002d5259e46e09bf682387edc8a7d
Source dataset
uspto-grants-2015_03
Patent number
US08986994B2

Reaction notes

Loading…