Hydrochloric Acid → HCID 86673657, compound

HRID 876161Notes

Reaction equation

HRID 876161 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[Cl:9][C:10]1[CH:16]=[CH:15][C:13]([NH2:14])=[CH:12][CH:11]=1.Cl>CC(O)C>[ClH:1].[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:14][C:13]2[CH:15]=[CH:16][C:10]([Cl:9])=[CH:11][CH:12]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 78124-ChloroanilineHCID 709434,6-Dichloropyrimidine

Product 1

HCID 86673657HCID 86673657, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
84 °C

Procedure

250 mg of 4,6-dichloropyrimidine and 165 mg of p-chloroaniline were dissolved in 2.5 mL of i-PrOH and 0.25 mL of 37% HCl were added. The mixture obtained was refluxed (84° C.) for 2.5 hours under nitrogen atmosphere. A colorless precipitate was formed which was collected by filtration. 6-Chloro-N-(4-chlorophenyl)pyrimidin-4-amine hydrochloride in the form of colorless crystals was obtained.

Workup

  1. customThe mixture obtained
  2. customA colorless precipitate was formed which
  3. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-da3df6e14b484195b71e2a28cfc47efe
Source dataset
uspto-grants-2015_03
Patent number
US08986994B2

Reaction notes

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