Hydrochloric Acid → HCID 86673659, compound

HRID 876167Notes

Reaction equation

HRID 876167 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[N+:9]([C:12]1[CH:13]=[C:14]([CH:16]=[CH:17][CH:18]=1)[NH2:15])([O-:11])=[O:10].Cl>CC(O)C>[ClH:1].[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:15][C:14]2[CH:16]=[CH:17][CH:18]=[C:12]([N+:9]([O-:11])=[O:10])[CH:13]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 74233-NitroanilineHCID 709434,6-Dichloropyrimidine

Product 1

HCID 86673659HCID 86673659, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
84 °C

Procedure

250 mg of 4,6-Dichloropyrimidine and 178 mg of m-nitroaniline were dissolved in 2.5 mL of i-PrOH and 0.25 mL of 37% HCl were added. The mixture obtained was refluxed (84° C.) for 4 hours under nitrogen atmosphere. A colorless precipitate was formed which was collected by filtration. 6-Chloro-N-(3-nitrophenyl)pyrimidin-4-amine hydrochloride in the form of bright yellow crystals was obtained.

Workup

  1. customThe mixture obtained
  2. customA colorless precipitate was formed which
  3. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-f210d5d5a5154aa1a298b87af2d374e5
Source dataset
uspto-grants-2015_03
Patent number
US08986994B2

Reaction notes

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