Ethanolamine → HCID 53261255, compound

HRID 876185Notes

Reaction equation

HRID 876185 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:11][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.CCOC(C)=O.[CH2:28]([CH2:30][NH2:31])[OH:29]>>[O:15]([C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:6]2[N:7]=[C:2]([NH:31][CH2:30][CH2:28][OH:29])[CH:3]=[CH:4][CH:5]=2)=[CH:10][CH:11]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 700EthanolamineHCID 8857Ethyl Acetate2×HCID 63587641HCID 63587641, compound

Product 1

HCID 53261255HCID 53261255, compoundYield 73%

Procedure

A mixture of 130 mg of 6-chloro-N-(4-phenoxyphenyl)pyridin-2-amine in 214 mg of ethanolamine was filled in a screw cap vial and was treated analogously to the method as set out in Example 16b, but using for flash column chromatography a solvent mixture of EtOAc:PE=1:1 instead of EtOAc:PE=3:1). 2-(6-(4-Phenoxyphenylamino)pyridin-2-ylamino)ethan-1-ol was obtained in the form of a brown oil.

Workup

  1. additionwas filled in a screw
  2. customcap vial
  3. additionwas treated analogously to the method

Sources & evidence

ORD record
ord-87d6a40ea22d4dc1b1b52bfae72ed37c
Source dataset
uspto-grants-2015_03
Patent number
US08986994B2

Reaction notes

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