反应详情

温度

0 °C

10.0 g (40.4 mmol) of the compound from Example 2A were initially charged in 135 ml of dichloromethane and cooled to 0° C., and 11.2 ml (8.2 g, 80.9 mmol) of triethylamine and 8.5 g (40.4 mmol) of 4-nitrophenyl chloroformate were added. The reaction mixture was allowed to warm to room temperature over a period of 2 h. For work-up, the mixture was twice washed with water, and the organic phase was dried over sodium sulphate. The solvent was removed under reduced pressure and the residue was dried under high vacuum. Yield: 16.5 g (83% of theory)

1. temperatureto warm to room temperature over a period of 2 h
2. washFor work-up, the mixture was twice washed with water
3. dry with materialthe organic phase was dried over sodium sulphate
4. customThe solvent was removed under reduced pressure
5. customthe residue was dried under high vacuum