tert-Butanol → tert-Butyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}carbamate

HRID 876347Notes

Reaction equation

HRID 876347 reaction equation
C([N:3]([CH2:6]C)CC)C.P(N=[N+]=[N-])(=O)(OC1C=CC=CC=1)[O:9]C1C=CC=CC=1.[N:27]1([C:33]([N:35]2[CH2:40][CH:39]([C:41]3[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[CH:43][CH:42]=3)[CH2:38][CH:37](C(O)=O)[CH2:36]2)=[O:34])[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1.[C:54]([OH:58])([CH3:57])([CH3:56])[CH3:55]>>[N:27]1([C:33]([N:35]2[CH2:40][CH:39]([C:41]3[CH:46]=[CH:45][C:44]([C:47]([F:49])([F:50])[F:48])=[CH:43][CH:42]=3)[CH2:38][CH:37]([NH:3][C:6](=[O:9])[O:58][C:54]([CH3:57])([CH3:56])[CH3:55])[CH2:36]2)=[O:34])[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1

Participants

5

Reactant 4

HCID 6386tert-ButanolHCID 8471TriethylamineHCID 123414Diphenylphosphoryl azideHCID 580024471-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 46931415tert-Butyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}carbamate

Procedure

Activated molecular sieves 4 Å (about 10 g), 2.16 ml (15.5 mmol) of triethylamine and 3.92 g (14.2 mmol) of diphenyl phosphorazidate were added to the carboxylic acid from Example 55A (5.00 g, 12.9 mmol) in tert-butanol (235 ml), and the mixture was stirred under reflux overnight. The reaction solution was cooled, and the molecular sieves were then filtered off and washed thoroughly with ethyl acetate. The solvent was removed under reduced pressure and the residue was taken up in ethyl acetate. After washing with 2 N aqueous hydrogen chloride solution, saturated aqueous sodium bicarbonate solution and water, the organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. The crude product was used for the next step without further purification. Yield: 5.53 g (89% of theory)

Workup

  1. temperatureunder reflux overnight
  2. temperatureThe reaction solution was cooled
  3. filtrationthe molecular sieves were then filtered off
  4. washwashed thoroughly with ethyl acetate
  5. customThe solvent was removed under reduced pressure
  6. washAfter washing with 2 N aqueous hydrogen chloride solution, saturated aqueous sodium bicarbonate solution and water
  7. dry with materialthe organic phase was dried over magnesium sulphate
  8. filtrationfiltered
  9. concentrationconcentrated under reduced pressure
  10. customThe crude product was used for the next step without further purification

Sources & evidence

ORD record
ord-0f8ff72a018f416ea706fb195ab3c6f3
Source dataset
uspto-grants-2015_03
Patent number
US08987248B2

Reaction notes

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