反应详情

A solution of n-BuLi (4.2 mL, 10.6 mmol) in THF was added to a solution of 1-bromo-2-(difluoromethyl)benzene 51 (2.0 g, 9.7 mmol) in THF (50 mL) at −78° C. The reaction mixture was stirred for 30 min and DMF (1.4 g, 19.3 mmol) was added. Stirring was continued for 1 h at −40° C. and the reaction was quenched by the addition of sat. aq NH4Cl. The crude mixture was extracted with Et2O, dried (MgSO4) and concentrated to give 52 (1.7 g, 94% yield).

1. stirringStirring
2. waitwas continued for 1 h at −40° C.
3. customthe reaction was quenched by the addition of sat. aq NH4Cl
4. extractionThe crude mixture was extracted with Et2O
5. dry with materialdried (MgSO4)
6. concentrationconcentrated