反应详情

To a solution of compound 9-5 (16.5 mg) in CH2Cl2 (1 mL), were added triethylamine (6.7 microL) and acetoxyacetyl chloride (5.1 microL) at 0° C. The reaction mixture was stirred at room temperature for 30 minutes. Then EtOAc and water were added into the mixture and it was extracted with EtOAc. The organic layer was washed with H2O, 1N HCl, sat. NaHCO3 aq. and brine, respectively and dried with anhydr. Na2SO4. The solvent was removed under reduced pressure to obtain compound 9-6 (20 mg) as a pale yellow amorphous solid.

1. extractionwas extracted with EtOAc
2. washThe organic layer was washed with H2O, 1N HCl, sat. NaHCO3 aq. and brine
3. customrespectively and dried with anhydr
4. customThe solvent was removed under reduced pressure