Hydroxylamine → HCID 86653953, compound

HRID 876586Notes

Reaction equation

HRID 876586 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][O:14][C@H:13]([C@@H:17]([OH:30])[C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][C:22]=3[Cl:29])=[O:19])[C:12]2=[O:31])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:32][OH:33]>CCO>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH2:16][CH2:15][O:14][C@H:13]([C@@H:17]([OH:30])[C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([C:27](=[N:32][OH:33])[NH2:28])=[CH:23][C:22]=3[Cl:29])=[O:19])[C:12]2=[O:31])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 67223362HCID 67223362, compound

Product 1

HCID 86653953HCID 86653953, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of compound 66-1 (60 mg) in EtOH (2 mL), was added 50% NH2OH aq. (22.4 microL). The reaction mixture was stirred at room temperature overnight. Then the mixture was concentrated in vacuo to obtain compound 66-2 (67 mg) as a colorless amorphous solid.

Workup

  1. concentrationThen the mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-35852d5b1e154766af4620bc6069db2b
Source dataset
uspto-grants-2015_03
Patent number
US08987242B2

Reaction notes

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