反应详情

To a stirred mixture of compound 93-3 (175 mg, 0.50 mmol), DMAP (12 mg, 20 mmol %), and 3-(4-aminophenyl)-1,2,4-oxadiazol-5(2H)-one 1 (177 mg, 2 eq) in MeCN (2.5 ml) at 0° C., EDCI (191 mg, 2 eq) was added. The resulting mixture was stirred at RT for 2 h. The volatile materials were removed on the rotavap. The residue was purified by silica gel chromatography (MeOH/DCM 0 to 10%) to give compound 96-1 (110 mg).

1. customThe volatile materials were removed on the rotavap
2. customThe residue was purified by silica gel chromatography (MeOH/DCM 0 to 10%)