Dimethylformamide dimethyl acetal → HCID 67002765, compound

HRID 876787Notes

Reaction equation

HRID 876787 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1.CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>CN(C=O)C>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([N:1]=[CH:12][N:13]([CH3:15])[CH3:14])=[N:3][CH:4]=1)#[N:7]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 8182602-Amino-5-cyanopyridine

Product 1

HCID 67002765HCID 67002765, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
130 °C

Procedure

To a stirred solution of 6-aminonicotinonitrile (L-1) (8.7 g, 73 mmol) in DMF (35 mL) was added N,N-dimethylformamide dimethyl acetal (35 mL, 294 mmol). The reaction mixture was heated to 130° C. overnight. After cooled to room temperature, the volatiles were removed under reduced pressure to afford the desired intermediate N′-(5-cyanopyridin-2-yl)-N,N-dimethylformamidine.

Workup

  1. temperatureAfter cooled to room temperature
  2. customthe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-c11a282bd6014f53a9d6546935bee143
Source dataset
uspto-grants-2015_03
Patent number
US08987269B2

Reaction notes

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