Formic Acid → HCID 178507597, compound

HRID 876795Notes

Reaction equation

HRID 876795 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]2[S:8]C(N)=[N:10][C:5]2=[CH:4][CH:3]=1.S([O-])([O-])=O.[Na+].[Na+].C(O)=O>[OH-].[Na+]>[NH2:10][C:5]1[C:6]([SH:8])=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=1

Participants

5

Reactant 3

HCID 284Formic AcidHCID 24437Sodium SulfiteHCID 42660645-chlorothiazolo[5,4-b]pyridin-2-amine

Product 1

HCID 178507597HCID 178507597, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

5-Chlorothiazolo[5,4-b]pyridin-2-amine (Q-2) (19 g, 103 mmol) containing sodium sulfite (2 g) was refluxed in 20% aqueous sodium hydroxide solution (150 mL) overnight. The solids were completely dissolved after 1 h, then cooled to room temperature. The solution was neutralized with formic acid. A precipitate was collected by filtration as the title compound (16.4 g).

Workup

  1. dissolutionThe solids were completely dissolved after 1 h
  2. filtrationA precipitate was collected by filtration as the title compound (16.4 g)

Sources & evidence

ORD record
ord-0c0faf03469e4a188507d29fc1fbc16b
Source dataset
uspto-grants-2015_03
Patent number
US08987269B2

Reaction notes

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