Hydrochloric Acid → 1H-thieno[3,2-c]pyrazole-5-carboxylic acid

HRID 876836Notes

Reaction equation

HRID 876836 reaction equation
[NH:1]1[C:5]2[CH:6]=[C:7]([C:9]([O:11]C)=[O:10])[S:8][C:4]=2[CH:3]=[N:2]1.O[Li].O.Cl>CO.O>[NH:1]1[C:5]2[CH:6]=[C:7]([C:9]([OH:11])=[O:10])[S:8][C:4]=2[CH:3]=[N:2]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 68289363methyl 1H-thieno[3,2-c]pyrazole-5-carboxylate

Product 1

HCID 596408271H-thieno[3,2-c]pyrazole-5-carboxylic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of methyl 1H-thieno[3,2-c]pyrazole-5-carboxylate (F-5) (4.2 g, 18.7 mmol) in MeOH (50 mL) was added a solution of LiOH.H2O (3.1 g, 74.8 mmol) in water (5 mL). The reaction mixture was stirred at room temperature overnight. Then 1N HCl was added to adjust to pH to ˜5, the resulting precipitate was collected and dried to afford the title compound.

Workup

  1. customthe resulting precipitate was collected
  2. customdried

Sources & evidence

ORD record
ord-1d2d95560a5443e484264750e70a9fe4
Source dataset
uspto-grants-2015_03
Patent number
US08987269B2

Reaction notes

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