Hydrochloric Acid → HCID 57377767, compound

HRID 877057Notes

Reaction equation

HRID 877057 reaction equation
C(OC(=O)[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:31]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)=[C:30]([NH:38][CH3:39])[N:21]4[N:22]=[C:23]5[C:28]([CH:27]=[C:26]([F:29])[CH:25]=[CH:24]5)=[C:20]4[N:19]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)(C)(C)C.Cl>O1CCOCC1>[NH2:7][C:8]1([C:12]2[CH:13]=[CH:14][C:15]([C:18]3[C:31]([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)=[C:30]([NH:38][CH3:39])[N:21]4[N:22]=[C:23]5[C:28]([CH:27]=[C:26]([F:29])[CH:25]=[CH:24]5)=[C:20]4[N:19]=3)=[CH:16][CH:17]=2)[CH2:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86702533HCID 86702533, compound

Product 1

HCID 57377767HCID 57377767, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

608 mg (1.13 mmol) (1-{4-[9-Fluoro-4-(methylamino)-3-phenylpyrimido[1,2-b]indazol-2-yl]phenyl}cyclobutyl)carbamic acid tert-butyl ester were treated with 4M hydrogen chloride in dioxane as described in the previous example. Purification by HPLC gave 54.3 mg (10.4%) of the title compound.

Workup

  1. customPurification by HPLC

Sources & evidence

ORD record
ord-49230d88931346f9a5eaf098bdc48c17
Source dataset
uspto-grants-2015_03
Patent number
US08987286B2

Reaction notes

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