HCID 86702545, compound → HCID 57378750, compound

HRID 877072Notes

Reaction equation

HRID 877072 reaction equation
C(OC([NH:8][C:9]1([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[C:36]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)=[CH:35][N:22]4[N:23]=[C:24]5[C:29]([CH:28]=[CH:27][CH:26]=[C:25]5/[CH:30]=[CH:31]/[C:32]([NH2:34])=[O:33])=[C:21]4[N:20]=3)=[CH:15][CH:14]=2)[CH2:12][CH2:11][CH2:10]1)=O)(C)(C)C>Cl.O1CCOCC1>[NH2:8][C:9]1([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[C:36]([C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)=[CH:35][N:22]4[N:23]=[C:24]5[C:29]([CH:28]=[CH:27][CH:26]=[C:25]5/[CH:30]=[CH:31]/[C:32]([NH2:34])=[O:33])=[C:21]4[N:20]=3)=[CH:15][CH:14]=2)[CH2:10][CH2:11][CH2:12]1

Participants

4

Reactant 1

HCID 86702545HCID 86702545, compound

Product 1

HCID 57378750HCID 57378750, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

281 mg of the crude (E)-3-[2-(4-{1-[(tert-Butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenyl-pyrimido[1,2-b]indazol-7-yl]acrylamide were stirred in 15.9 mL 4M hydrogen chloride in dioxane for 18 hours at room temperature as described in example 13 (step 2). After the usual work-up and purification by HPLC 28.5 mg (12.4%) of the title compound were obtained.

Workup

  1. customAfter the usual work-up and purification by HPLC 28.5 mg (12.4%) of the title compound
  2. customwere obtained

Sources & evidence

ORD record
ord-40405b395df0435b9d544caa5cb52248
Source dataset
uspto-grants-2015_03
Patent number
US08987286B2

Reaction notes

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