Trifluoroacetic acid → HCID 58136718, compound

HRID 877248Notes

Reaction equation

HRID 877248 reaction equation
[CH:1]1([CH:6]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][N:21]3[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:22]3=[O:31])=[CH:16][CH:15]=2)[C:7]([O:9]C(C)(C)C)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>ClCCl>[CH:1]1([CH:6]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][N:21]3[CH:26]=[C:25]([C:27]([F:28])([F:29])[F:30])[CH:24]=[CH:23][C:22]3=[O:31])=[CH:16][CH:15]=2)[C:7]([OH:9])=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58136578HCID 58136578, compound

Product 1

HCID 58136718HCID 58136718, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

390 mg (0.90 mmol) of tert-butyl(+/−)-cyclopentyl(4-{[2-oxo-5-(trifluoromethyl)pyridin-1(2H)-yl]methyl}phenyl)ethanoate were initially charged in 2.7 ml of dichloromethane, and 690 μl of trifluoroacetic acid were added. The reaction mixture was stirred at RT for 2 h and then concentrated under reduced pressure, and the residue was dried under high vacuum. This gave 523 mg of product, which was used without further purification.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customthe residue was dried under high vacuum
  3. customThis gave 523 mg of product, which was used without further purification

Sources & evidence

ORD record
ord-87f337684f5e4391bd34eabd920a57c8
Source dataset
uspto-grants-2015_03
Patent number
US08987256B2

Reaction notes

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