反应详情

A mixture of methyl 3-formylbenzoate (2.5 g, 15.2 mmol), ethylene glycol (4.2 mL, 75 mmol) and para-toluenesulfonic acid monohydrate (0.29 g, 1.52 mmol) in toluene (60 mL) was heated at reflux under Dean and Stark conditions for 4 hours. The reaction mixture was diluted with ethyl acetate and washed sequentially with saturated sodium hydrogen carbonate and brine. The organic phase was dried (magnesium sulfate), filtered and the solvent evaporated at reduced pressure to afford the title compound (3.09 g, 98%).

1. temperaturewas heated
2. temperatureat reflux under Dean and Stark conditions for 4 hours
3. washwashed sequentially with saturated sodium hydrogen carbonate and brine
4. dry with materialThe organic phase was dried (magnesium sulfate)
5. filtrationfiltered
6. customthe solvent evaporated at reduced pressure