Hydrochloric Acid → HCID 86668958, compound

HRID 877351Notes

Reaction equation

HRID 877351 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:16]2[N:17]=[N:18][N:19]([CH3:21])[CH:20]=2)[NH:9]S(C(C)(C)C)=O)=[CH:4][CH:3]=1.[ClH:22]>CO.C(OCC)C>[Cl-:22].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:16]2[N:17]=[N:18][N:19]([CH3:21])[CH:20]=2)[NH3+:9])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67170071HCID 67170071, compound

Product 1

HCID 86668958HCID 86668958, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 0.71 g (1.9 mmol) N-[(S)-(4-bromophenyl)(1-methyl-1H-1,2,3-triazol-4-yl)methyl]-2-methylpropane-2-sulfinamide in 5.0 ml MeOH was added 1.4 mL (2.8 mmol) 2.0M HCl in diethyl ether. After 30 min at room temperature, the reaction mixture was concentrated in vacuo to afford (S)-(4-bromophenyl)(1-methyl-1H-1,2,3-triazol-4-yl)methanaminium chloride. ES-MS [M+1]+=269.0.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-af5a2c5950724e5db7ad3e247fd442c0
Source dataset
uspto-grants-2015_03
Patent number
US08987310B2

Reaction notes

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