Hydrochloric Acid → HCID 178491234, compound

HRID 877387Notes

Reaction equation

HRID 877387 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:17]2[N:18]=[C:19]([CH3:22])[NH:20][CH:21]=2)[NH:10]S(C(C)(C)C)=O)=[CH:5][CH:4]=1.[ClH:23].CCOCC>CO>[Cl-:23].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([C:17]2[N:18]=[C:19]([CH3:22])[NH:20][CH:21]=2)[NH3+:10])=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 178491267HCID 178491267, compound

Product 1

HCID 178491234HCID 178491234, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-[(4-methoxyphenyl)(2-methyl-1H-imidazol-4-yl)methyl]-2-methylpropane-2-sulfinamide (0.735 mg, 2.287 mmol) in 10.0 ml of MeOH was added 2.0N HCl in Et2O (11.43 ml, 22.87 mmol), and the mixture was stirred at RT for 30 min. Solvent removed and the residue was dried under vacuum to give the crude title compound (0.568 g, 98%). ES-MS [M+1]+: m/z 218.1. This intermediate was carried over to the next step without further purification and characterization.

Workup

  1. customSolvent removed
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-08d4917fc9c647379c4c59dcaf5c8172
Source dataset
uspto-grants-2015_03
Patent number
US08987310B2

Reaction notes

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