反应详情

温度

110 °C

To an ice-cold mixture of POCl3 (1.60 mL) and DMF (1 mL) in a microwave vial, 5-iodo-3-trifluoromethyl-2-pyridinol (1 g, 3.47 mmol) is added. The vial is sealed and heated 20 min at 110° C. The reaction mixture cooled at room temperature is poured into ice cold water. The product precipitates. The precipitate is filtered, washed with cold water and dried to afford 661 mg (62%) of a light brown powder.

1. additionis added
2. customThe vial is sealed
3. temperatureThe reaction mixture cooled at room temperature
4. additionis poured into ice cold water
5. customThe product precipitates
6. filtrationThe precipitate is filtered
7. washwashed with cold water
8. customdried