Benzyl acetone → HCID 22937709, compound

HRID 878531Notes

Reaction equation

HRID 878531 reaction equation
[C:1]1([CH2:7][CH2:8][C:9](=[O:11])[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:12][N:13]([CH:15](OC)OC)[CH3:14]>CN(C=O)C>[CH3:12][N:13]([CH3:15])/[CH:14]=[CH:10]/[C:9](=[O:11])[CH2:8][CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 17355Benzyl acetoneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 22937709HCID 22937709, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 4-phenylbutan-2-one (3.96 g, 20 mmol) and DMF-DMA (2.4 g, 20 mmol) in DMF (10 mL) was stirred at 100° C. overnight. The reaction mixture was cooled, concentrated, and purified by silica gel column (PE/EA=4:1˜2:1) to give the title compound (1.5 g, 37%) as a yellow oil.

Workup

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated
  3. custompurified by silica gel column (PE/EA=4:1˜2:1)

Sources & evidence

ORD record
ord-bcbc67b5316b40bd97495623e17f1f9c
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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