Hydrochloric Acid → HCID 86698256, compound

HRID 879243Notes

Reaction equation

HRID 879243 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:9]([NH:11][NH:12]C(=O)C1C=CC=CC=1)=[O:10])(C)(C)C.[ClH:29].[O:30]1[CH2:35][CH2:34]OCC1>>[NH2:7][C@@H:8]([CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[C:9]([N:11]([C:35](=[O:30])[C:34]1[CH:23]=[CH:22][CH:21]=[CH:8][CH:9]=1)[NH:12][Cl:29])=[O:10]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 31808933HCID 31808933, compound2×

Product 1

HCID 86698256HCID 86698256, compound

Procedure

313 mg (818 μmol) of tert.-butyl-[(2S)-1-(2-benzoylhydrazino)-1-oxo-3-phenylpropan-2-yl]carbamate (intermediate 34) were stirred in 13 ml of a 4 N hydrogen chloride solution diluted in dioxane and stirred for 1 hour at RT. Then the reaction composition was evaporated and the residue vacuum dried. The yield was 255 mg (92% o. th.) of the title compound.

Workup

  1. customThen the reaction composition was evaporated
  2. customthe residue vacuum dried

Sources & evidence

ORD record
ord-e75e1fa36d00412fb28b94145abca798
Source dataset
uspto-grants-2015_03
Patent number
US08987209B2

Reaction notes

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