HCID 86700409, compound → HCID 86700408, compound

HRID 879594Notes

Reaction equation

HRID 879594 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([CH:11]3[CH2:16][NH:15][C:14](=O)[CH2:13][O:12]3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1>C1COCC1>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([CH:11]3[O:12][CH2:13][CH2:14][NH:15][CH2:16]3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1

Participants

3

Reactant 1

HCID 86700409HCID 86700409, compound

Product 1

HCID 86700408HCID 86700408, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of 6-(1-methyl-1H-indazol-5-yl)morpholin-3-one (17.8 mg, 0.077 mmol) in THF was added BH3 in THF (1M, mmol). The resulting mixture was stirred at room temperature for 10 hr. The crude compound was evaporated to dryness and used for the next step without further purification. LCMS-ESI+: calc'd for C12H15N3O: 218.1 (M+H+); found: 218.2 (M+H+).

Workup

  1. customThe crude compound was evaporated to dryness
  2. customused for the next step without further purification

Sources & evidence

ORD record
ord-af3458411c5147519def525373ce9cb5
Source dataset
uspto-grants-2015_03
Patent number
US08987250B2

Reaction notes

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