反应详情

温度

80 °C

Iron powder (61.42 g, 1 mol) and hydrochloric acid (6 mL) were added to 90% EtOH (25 v/w, 1210 mL). The mixture was warmed up to 80° C. and stirred for 15 min. Then Intermediate VIII (48.42 g, 0.11 mol) was added in batch to the reaction solution. After the addition completion, the reaction was conducted under reflux for 2 h. After completion of the reaction, the reaction was filtered by suction when h is still hot. The filtrate was collected. The solvate was evaporated off to produce a yellow solid (43 g) in a yield of 95%.

1. temperatureunder reflux for 2 h
2. customAfter completion of the reaction
3. filtrationthe reaction was filtered by suction when h
4. customThe filtrate was collected
5. customThe solvate was evaporated off