反应详情

To a stirred solution of ethyl 5-[2,4-bis(benzyloxy)-6-(4-nitrophenoxy)phenyl]isoxazole-3-carboxylate (5 g, 9 mmol) in ethanol (150 mL) was added 1.5 M KOH solution (9 mL, 13.5 mmol, 1.5 eq). After stirring for 3 hours at room temperature, 2 M HCl solution (7.5 mL) was added and the suspension taken up in ethyl acetate was washed with brine. After drying and removal of the solvent, the residue was rinsed with a small volume of acetone and filtered off, to give after drying, the title compound (4.1 g, 86% yield).

1. washwas washed with brine
2. customAfter drying
3. customremoval of the solvent
4. washthe residue was rinsed with a small volume of acetone
5. filtrationfiltered off
6. customto give
7. customafter drying