Dichloromethane → HCID 59454526, compound

HRID 880397Notes

Reaction equation

HRID 880397 reaction equation
[CH:1]1([N:5]2C[CH2:9][N:8](C([C@@H]3C[C@H]3C3C=C(C=CC=3)C(N)=O)=O)[C@@H:7](C)[CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[C:26](O)([C:28](F)(F)F)=O.[CH2:33](Cl)Cl>>[CH:1]1([N:5]2[CH2:6][CH2:7][NH:8][CH2:9][C:28]2([CH3:26])[CH3:33])[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 46896396HCID 46896396, compound

Product 1

HCID 59454526HCID 59454526, compound

Procedure

Intermediate 1 (0.443 g, 1.65 mmol) was dissolved in DCM (10 mL) and TFA (5.00 mL) was added. The reaction mixture was stirred for 1.5 h, then was concentrated under reduced pressure and dried under vacuum. The crude title compound was used in the next step without purification.

Workup

  1. concentrationwas concentrated under reduced pressure
  2. customdried under vacuum
  3. customThe crude title compound was used in the next step without purification

Sources & evidence

ORD record
ord-30fe79f3df534bb6bbd0ef3114b93ce2
Source dataset
uspto-grants-2015_03
Patent number
US08993577B2

Reaction notes

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