2-Chloro-4-methylpyridine → HCID 66914673, compound

HRID 880401Notes

Reaction equation

HRID 880401 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl[C:17]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][N:18]=1>COCCOCCOC>[CH3:23][C:21]1[CH:20]=[CH:19][N:18]=[C:17]([N:13]2[CH2:14][CH2:15][N:10]([C:7]3[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=3)[CH2:11][CH2:12]2)[CH:22]=1

Participants

4

Reactant 2

HCID 772482-Chloro-4-methylpyridineHCID 804471-(4-Nitrophenyl)piperazine

Product 1

HCID 66914673HCID 66914673, compound

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Procedure

From 1-(4-nitro-phenyl)-piperazine and 2-chloro-4-methylpyridine, by heating in diglyme to give 1-(4-methyl-pyridin-2-yl)-4-(4-nitro-phenyl)-piperazine then catalytic hydrogenation over Raney nickel in methanol.

Sources & evidence

ORD record
ord-6c7c5d6e45094f809f539ed9c717c82b
Source dataset
uspto-grants-2015_03
Patent number
US08993574B2

Reaction notes

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