反应详情

Piperidine (0.80 g, 9.42 mmol) was added to a solution of 3,4-difluoro-nitro benzene (1.0 g, 6.28 mmol) in acetonitrile (15 mL) and diisopropyl ethylamine (1.62 g, 12.57 mmol) and the mixture was refluxed for 3 h. The acetonitrile was removed in vacuo and the residue was diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over anhydrous sodium sulphate and concentrated in vacuo to afford 1-(2-fluoro-4-nitro-phenyl)piperidine (1.3 g, 92%) as a yellow liquid.

1. temperaturethe mixture was refluxed for 3 h
2. customThe acetonitrile was removed in vacuo
3. additionthe residue was diluted with water
4. extractionextracted with ethyl acetate
5. washThe combined organic extracts were washed with brine
6. dry with materialdried over anhydrous sodium sulphate
7. concentrationconcentrated in vacuo