反应详情

To a solution of 4-piperidone monohydrate hydrochloride salt (2.2 g, 14.32 mmol, 1 eq) in acetonitrile, 2-bromoethyl methyl ether (5.9 ml, 28.6 mmol, 2 eq), and K2CO3 (2 eq) was added and heated at reflux overnight. Reaction extracted into dichloromethane (50 ml), washed with water (2×50 ml), dried (MgSO4), and evaporated in vacuo to give 1-(2-methoxy-ethyl)piperidin-4-one as a yellow oil.

1. temperatureheated
2. temperatureat reflux overnight
3. customReaction
4. extractionextracted into dichloromethane (50 ml)
5. washwashed with water (2×50 ml)
6. dry with materialdried (MgSO4)
7. customevaporated in vacuo