Trifluoroacetic acid → HCID 58233970, compound

HRID 881523Notes

Reaction equation

HRID 881523 reaction equation
C(O)(C(F)(F)F)=O.[CH3:8][NH:9][C:10]1[N:15]=[CH:14][C:13]([C:16]2[N:17]=[C:18]([N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)[C:19]3[CH:24]=[C:23]([CH2:25][N:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[S:22][C:20]=3[N:21]=2)=[CH:12][N:11]=1.[C:38](O)(=[O:42])[C@H:39]([CH3:41])[OH:40]>>[OH:40][C@@H:39]([CH3:41])[C:38]([N:29]1[CH2:30][CH2:31][N:26]([CH2:25][C:23]2[S:22][C:20]3[N:21]=[C:16]([C:13]4[CH:14]=[N:15][C:10]([NH:9][CH3:8])=[N:11][CH:12]=4)[N:17]=[C:18]([N:32]4[CH2:33][CH2:34][O:35][CH2:36][CH2:37]4)[C:19]=3[CH:24]=2)[CH2:27][CH2:28]1)=[O:42]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 107689L-Lactic AcidHCID 66934078HCID 66934078, compound

Product 1

HCID 58233970HCID 58233970, compound

Procedure

The crude TFA salt of N-methyl-5-(4-morpholino-6-((piperazin-1-yl)methyl)thieno[2,3-d]pyrimidin-2-yl)pyrimidin-2-amine was reacted with L-lactic acid via General Procedure B to give 28.3 mg of 388 after reverse phase HPLC purification. MS (Q1) 499.3 (M)+

Sources & evidence

ORD record
ord-07e04065ad124f7a9ca58de33dcedc26
Source dataset
uspto-grants-2015_03
Patent number
US08993563B2

Reaction notes

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