Dichloromethane → rac-(2'S,3'S,4'S)-6-chloro-2'-(3-chloro-2-fluoro-phenyl)-4'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid (1-methanesulfonyl-piperidin-4-ylethyl)-amide
Reaction equation
[CH3:47][CH2:48][N:49]([CH2:50][CH3:51])[CH2:52][CH3:53].[CH3:54][S:55]([Cl:56])(=[O:57])=[O:58].[Cl:59][CH2:60][Cl:61].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][CH2:15][NH:16][C:17](=[O:18])[N:19]2[CH:20]([c:39]3[c:40]([F:46])[c:41]([Cl:45])[cH:42][cH:43][cH:44]3)[C:21]3([C:22](=[O:31])[NH:23][c:24]4[cH:25][c:26]([Cl:30])[cH:27][cH:28][c:29]43)[CH:32]([CH2:34][C:35]([CH3:36])([CH3:37])[CH3:38])[CH2:33]2)[CH2:12][CH2:13]1>>[N:8]1([S:55]([CH3:54])(=[O:57])=[O:58])[CH2:9][CH2:10][CH:11]([CH2:14][CH2:15][NH:16][C:17](=[O:18])[N:19]2[CH:20]([c:39]3[c:40]([F:46])[c:41]([Cl:45])[cH:42][cH:43][cH:44]3)[C:21]3([C:22](=[O:31])[NH:23][c:24]4[cH:25][c:26]([Cl:30])[cH:27][cH:28][c:29]43)[CH:32]([CH2:34][C:35]([CH3:36])([CH3:37])[CH3:38])[CH2:33]2)[CH2:12][CH2:13]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-6c8925a228a84fd881742657120424e4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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