Hydrochloric Acid → HCID 68753672, compound

HRID 881907Notes

Reaction equation

HRID 881907 reaction equation
[CH2:1]([O:3][C:4](=[O:32])[C@@H:5]([CH3:31])[CH2:6][CH:7]([NH:23]C(OC(C)(C)C)=O)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH3:22])=[CH:11][CH:10]=1)[CH3:2].[ClH:33]>C(Cl)Cl.O1CCOCC1>[ClH:33].[CH2:1]([O:3][C:4](=[O:32])[C@@H:5]([CH3:31])[CH2:6][CH:7]([NH2:23])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH3:22])=[CH:11][CH:10]=1)[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68747771HCID 68747771, compound

Product 1

HCID 68753672HCID 68753672, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

Next, to a solution of (S)-4-tert-butoxycarbonylamino-5-(2′-methoxy-biphenyl-4-yl)-2-methyl-pentanoic acid ethyl ester (473 mg, 1.017 mmol) in DCM (5 ml) was added HCl in dioxane (4M, 1 ml), and the resulting mixture was stirred at room temperature for 2 hours. Then, the mixture was concentrated on under reduced pressure. The obtained residue was used for next step without further purification. HPLC Retention time 1.28 minutes (condition A): MS 342.4 (M+1).

Workup

  1. concentrationThen, the mixture was concentrated on under reduced pressure
  2. customThe obtained residue was used for next step without further purification

Sources & evidence

ORD record
ord-6f06f89e3f46401cb29efcc197a0ae71
Source dataset
uspto-grants-2015_03
Patent number
US08993631B2

Reaction notes

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