Hydrochloric Acid → HCID 66629209, compound

HRID 882345Notes

Reaction equation

HRID 882345 reaction equation
[ClH:1].[CH3:2][C:3]1[N:7]=[C:6]([CH2:8][N:9]([C@H:17]2[CH2:19][C@H:18]2[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)C(=O)OC(C)(C)C)[O:5][N:4]=1>CCOCC>[ClH:1].[CH3:2][C:3]1[N:7]=[C:6]([CH2:8][NH:9][C@@H:17]2[CH2:19][C@H:18]2[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[O:5][N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66629560HCID 66629560, compound

Product 1

HCID 66629209HCID 66629209, compoundYield 12.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

HCl 2N in Et2O was added to tert-butyl (3-methyl-1,2,4-oxadiazol-5-yl)methyl((1S,2S)-2-phenylcyclopropyl)carbamate (35 mg, 0.106 mmol). The Et2O was decanted and the solid was washed twice with 5 mL of Et2O. The solid was dried by vacuum to get (trans)-N-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-2-phenylcyclopropanamine hydrochloride (14 mg. Yield 12.8%)

Workup

  1. customThe Et2O was decanted
  2. washthe solid was washed twice with 5 mL of Et2O
  3. customThe solid was dried by vacuum

Sources & evidence

ORD record
ord-7f89c4d9dd6f44618bb9cbccf84048cf
Source dataset
uspto-grants-2015_03
Patent number
US08993808B2

Reaction notes

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