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A mixture of trichloromethylsilane (0.12 ml, 1.0 mmol) and Grignard reagent, which was prepared from 2-((tert-butyldimethylsilyl)oxy)benzyl bromide (IIa) (1.54 g, 5.0 mmol) and magnesium (1.2 g, 50 mmol) in tetrahydrofuran (12 mL), was stirred for 3 days. The reaction was quenched with satd. ammonium chloride (50 mL). The mixture was extracted with hexanes (3×50 mL). Purification by flash column chromatography (hexane/ethyl acetate=50:1, v/v) provided compound Ma (0.51 g, 72%) as a colorless oil.

1. customThe reaction was quenched with satd
2. extractionThe mixture was extracted with hexanes (3×50 mL)
3. customPurification by flash column chromatography (hexane/ethyl acetate=50:1
4. customv/v) provided compound Ma (0.51 g, 72%) as a colorless oil