Trifluoroacetic acid → Ethyl-(1S,2R)-1-amino-2-phenylcyclopropanecarboxylate trifluoroacetate

HRID 882580Notes

Reaction equation

HRID 882580 reaction equation
C(OC([NH:8][C@@:9]1([C:18]([OH:20])=[O:19])[CH2:11][C@@H:10]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=O)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>C(O)C>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[NH2:8][C@@:9]1([C:18]([O:20][CH2:22][CH3:23])=[O:19])[CH2:11][C@@H:10]1[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 7009512(1S,2R)-N-Boc-1-amino-2-phenylcyclopropanecarboxylic acid

Product 1

HCID 86678341Ethyl-(1S,2R)-1-amino-2-phenylcyclopropanecarboxylate trifluoroacetate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared by standard methods, by esterifying commercially available (1S,2R)-1-[(tert-butoxycarbonyl)amino]-2-phenylcyclopropanecarboxylic acid with ethanol and subsequent Boc detachment with trifluoroacetic acid.

Sources & evidence

ORD record
ord-c93405c8754e4f1882819b8547f69384
Source dataset
uspto-grants-2015_03
Patent number
US08992932B2

Reaction notes

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