Trifluoroacetic acid → HCID 70980510, compound

HRID 882582Notes

Reaction equation

HRID 882582 reaction equation
[O:1]=[C:2]1[CH:6]=[CH:5][C:4](=[O:7])[N:3]1[CH2:8][CH2:9][C:10]([CH3:23])([CH3:22])[C:11]([NH:13][NH:14]C(OC(C)(C)C)=O)=[O:12].[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>ClCCl>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[O:7]=[C:4]1[CH:5]=[CH:6][C:2](=[O:1])[N:3]1[CH2:8][CH2:9][C:10]([CH3:23])([CH3:22])[C:11]([NH:13][NH2:14])=[O:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71004159HCID 71004159, compound

Product 1

HCID 70980510HCID 70980510, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

50 mg (154 mmol) of tert-butyl 2-[4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2,2-dimethylbutanoyl]hydrazinecarboxylate were dissolved in 2 ml of dichloromethane, and 0.4 ml of trifluoroacetic acid was added. The reaction mixture was stirred at RT for 30 min and then concentrated. 55.2 mg (93% purity, 99% of theory) of the title compound were obtained.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-54ccdffeb88244fc8bb6b5bac6359c8b
Source dataset
uspto-grants-2015_03
Patent number
US08992932B2

Reaction notes

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