Hydrochloric Acid → HCID 71294511, compound

HRID 882584Notes

Reaction equation

HRID 882584 reaction equation
C(OC([NH:8][C@H:9]([C:17]([O:19][CH2:20][C:21]12[CH2:30][CH:25]3[CH2:26][CH:27]([CH2:29][CH:23]([CH2:24]3)[CH2:22]1)[CH2:28]2)=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=O)(C)(C)C.[ClH:31]>O1CCOCC1>[ClH:31].[NH2:8][C@H:9]([C:17]([O:19][CH2:20][C:21]12[CH2:30][CH:25]3[CH2:24][CH:23]([CH2:29][CH:27]([CH2:26]3)[CH2:28]1)[CH2:22]2)=[O:18])[CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66836374HCID 66836374, compound2×

Product 1

HCID 71294511HCID 71294511, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

769 mg (1.86 mmol) of adamantan-1-ylmethyl N-(tert-butoxycarbonyl)-L-phenylalaninate (Intermediate 13) were dissolved in 25 ml of a 4 N solution of hydrogen chloride in dioxane and stirred at RT for 1 h. Subsequently, the reaction mixture was concentrated and the residue was dried under reduced pressure. 619 mg (95% of theory) of the title compound were obtained.

Workup

  1. concentrationSubsequently, the reaction mixture was concentrated
  2. customthe residue was dried under reduced pressure

Sources & evidence

ORD record
ord-3bf3835649fa4eabac6db8c1a223ada0
Source dataset
uspto-grants-2015_03
Patent number
US08992932B2

Reaction notes

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